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Furthermore, GSTs are additionally identified as regulators of cellular signaling pathways, thereby influencing cell proliferation or apoptosis ( in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac ( HepG2 cells have been used for decades as a test system for studies involving hepatotoxic compounds

Elevated fumarate levels have also been linked to mitochondrial metabolic rewiring in aggressive high-grade prostate cancer [63]

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In contrast, Ca 2+ entry from the extracellular space may be of minor importance [97]